SS-31 (Elamipretide) is a small, cell-permeable tetrapeptide that selectively targets the inner mitochondrial membrane. It is widely studied in mitochondrial-dysfunction research.
Cardiolipin-selective binding
Targets inner mitochondrial membrane
Studied in bioenergetics research
SS-31 binds cardiolipin on the inner mitochondrial membrane, and is proposed to stabilise the electron-transport chain, reduce reactive oxygen species production and improve ATP synthesis efficiency.
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