Retatrutide is a triple agonist peptide targeting GLP-1, GIP and glucagon receptors. It is currently in Phase 3 trials and is being investigated for its combined metabolic effects on energy balance and glucose handling.
Triple GLP-1 / GIP / glucagon agonist
Phase 3 investigational compound
Studied for energy-expenditure effects
Retatrutide activates three incretin-related receptors. Co-activation of the glucagon receptor is proposed to increase energy expenditure, while GLP-1 and GIP receptor activity improve glucose-dependent insulin secretion and reduce appetite.
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